膳食模式与胰腺癌风险

 

(意)Bosetti C,Bravi F,Turati F,Edefonti V,Polesel J,Decarli A,Negri E,Talamini R,Franceschi S,La Vecchia C,Zeegers MP

【编者导读】一项意大利病例对照研究项目,对326例胰腺癌病例和652例频数匹配对照进行了研究,结果发现:以富含蔬菜水果为主的饮食与罹患胰腺癌呈负相关,而以富含肉类以及其他动物制品为主的饮食、以(精)谷物和高糖为主的饮食与罹患胰腺癌呈正相关。

摘要

目的(Purpose):

食物和/或营养组合在罹患胰腺癌的风险中所扮演的角色,目前很少有可以利用的数据。为了探索膳食模式与胰腺癌之间的潜在关系,并提供更多的相关信息,我们在意大利的病例对照研究(case-control study)中对28种主要营养物质进行了主成分因子分析(principal component factor analysis)。

方法(Methods):

本研究对象包括326例胰腺癌病例以及652例频数匹配对照,对照组来自于非肿瘤疾患的住院患者。膳食信息的采集是通过有效的可重复的食物频率调查问卷进行。调整社会人口学变量(sociodemographic variables)和胰腺癌主要的公认危险因素后,采用了多因素logistic回归模型(Multiple logistic regression models)估算每一种膳食模式与胰腺癌的优势比(odds ratios,OR)。

结果(Results):

我们确认了四种膳食模式,分别是:“动物制品”(”animal products”)、“不饱和脂肪”(”unsaturated fats”)、“维生素与纤维素”(”vitamins and fiber”)以及“富含淀粉”(”starch rich”),这四种模式可以解释75%所研究的群体中营养摄入总方差(total variance)。在允许所有四种膳食模式后,研究发现动物制品膳食模式和富含淀粉膳食模式与胰腺癌之间呈正相关,最高与最低四分位数间的优势比(OR)分别为2.03【95%置信区间(CI)为1.29~3.19】和1.69(95%CI为1.02~2.79);而维生素与纤维素膳食模式与胰腺癌呈负相关(OR为0.55,95%CI为0.35~0.86);而不饱和脂肪膳食模式与胰腺癌之间无关联(OR为1.13,95%CI为0.71~1.78)。

结论(Conclusions):

富含大量肉类以及其他动物制品以及以(精)谷物和高糖为主的饮食,与胰腺癌呈正相关,而富含水果蔬菜的饮食与胰腺癌呈负相关。

来源:意大利米兰马里奥•内格里药理学研究学会,流行病学系

发表于:2013年5月《流行病学年鉴》

doi:10.1016/j.annepidem.2012.12.005.

PMID:23332711

翻译:悠悠步行者

http://www.ncbi.nlm.nih.gov/pubmed/23332711

 

Ann Epidemiol.2013 Mar;23(3):124-8. doi: 10.1016/j.annepidem.2012.12.005. Epub 2013 Jan 16.

Nutrient-based dietary patterns and pancreatic cancer risk.

Bosetti C, Bravi F, Turati F, Edefonti V, Polesel J, Decarli A, Negri E, Talamini R, Franceschi S, La Vecchia C, Zeegers MP.

Source

Dipartimento di Epidemiologia, Istituto di Ricerche Farmacologiche Mario Negri Milan, Italy. cristina.bosetti@marionegri.it

Abstract

PURPOSE:

Few data are available on the role of combinations of foods and/or nutrients on pancreatic cancer risk. To add further information on dietary patterns potentially associated to pancreatic cancer, we applied an exploratory principal component factor analysis on 28 major nutrients derived from an Italian case-control study.

METHODS:

Cases were 326 incident pancreatic cancer cases and controls 652 frequency-matched controls admitted to hospital for non-neoplastic diseases. Dietary information was collected through a validated and reproducible food frequency questionnaire. Multiple logistic regression models adjusted for sociodemographic variables and major recognized risk factors for pancreatic cancer were used to estimate the odds ratios (OR) of pancreatic cancer for each dietary pattern.

RESULTS:

We identified four dietary patterns-named “animal products,” “unsaturated fats,” “vitamins and fiber,” and “starch rich,” that explain 75% of the total variance in nutrient intake in this population. After allowing for all the four patterns, positive associations were found for the animal products and the starch rich patterns, the OR for the highest versus the lowest quartiles being 2.03 (95% confidence interval [CI], 1.29-3.19) and 1.69 (95% CI, 1.02-2.79), respectively; an inverse association emerged for the vitamins and fiber pattern (OR, 0.55; 95% CI, 0.35-0.86), whereas no association was observed for the unsaturated fats pattern (OR, 1.13; 95% CI, 0.71-1.78).

CONCLUSIONS:

A diet characterized by a high consumption of meat and other animal products, as well as of (refined) cereals and sugars, is positively associated with pancreatic cancer risk, whereas a diet rich in fruit and vegetables is inversely associated.

Copyright © 2013 Elsevier Inc. All rights reserved.